RECENT DIAGNOSIS
- Clinicopathological studies that 25% of cases have different diagnosis.
- Special proteins like tau,alpha synnuclein play a major role.
- Immunohistochemistry:LEWY BODIES –hallmark of parkinsonism
TAU PROTEIN DEPOSITS
- Hereditary factors : 13 different loci have been associated.
- Oxidative stress,impairment in mitochondrial complex 1 are also responsible.
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